Thermic effect of food (TEF) is the amount of energy expenditure above the resting metabolic rate due to the cost of processing food for use and storage. The effect varies substantially for different food components. The mechanism is unknown.

A commonly used estimate of the thermic effect of food is about 10% of one's caloric intake. 

The primary determinants of daily thermic effect are:

  1. the total caloric content of the meals,
  2. the macronutrient composition of the meals ingested.

Macronutrients:

The thermic effect of food is the energy required for digestion, absorption, and disposal of ingested nutrients, and depends on the composition of the food consumed:

  • Protein: 20-35 % of the energy consumed,
  • Carbohydrates and fats5-15 %.

Meal frequency has little to no thermic effect. 

Insulin

Thermic effect also depends on the insulin sensitivity of the individual, with more insulin-sensitive individuals having a significant effect while individuals with increasing resistance have negligible to zero effects. Both insulin resistance and obesity are independently associated with impaired thermic effect of food at rest, but "the responsiveness of thermogenesis to exercise before a meal is related to the obese state and not independently to insulin resistance per se."

Exercise

The thermic effect of food is marginally increased by 7-8 calories per hour with exercise:

  • aerobic training of sufficient duration and intensity
  • and by anaerobic weight training.

"Negative"  Caloric Balance

Celery, grapefruit, lemon, lime, apple, lettuce, broccoli, and cabbage are often claimed to have negative caloric balance, requiring more energy to digest than recovered from the food. There is no scientific evidence to show that any of these foods have a negative caloric impact.

Negative Calories

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